Guanylyl Cyclase-A Receptor Activation With Natriuretic Propeptides ∗
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-A gene.
Activation of natriuretic peptide receptor-A (NPRA) produces the second messenger cGMP, which plays a pivotal role in maintaining blood pressure and cardiovascular homeostasis. In the present study, we have examined the role of trans-acting factor Ets-1 in transcriptional regulation of Npr1 gene (coding for NPRA). Using deletional analysis of the Npr1 promoter, we have defined a 400 base pair (...
متن کاملC-type natriuretic peptide neuromodulates independently of guanylyl cyclase activation.
Of the four endogenous members of the natriuretic peptide family, only atrial natriuretic peptide has been demonstrated to have neuromodulatory effects. This study compares the neuromodulatory effects of atrial natriuretic peptide and a recently identified natriuretic peptide, C-type natriuretic peptide, in the rabbit isolated vas deferens. The ability of these peptides to alter cyclic nucleoti...
متن کاملA splice variant of the guanylyl cyclase-A receptor interferes with atrial natriuretic peptide (ANP) signaling
Background Activation of the homodimeric transmembrane guanylyl cyclase-A (GC-A) receptor upon binding of its extracellular ligands, atrial (ANP) and B-type (BNP) natriuretic peptides, leads to cyclic GMP formation in many types of cells. This NP/GC-A pathway has a critical role in the endocrine regulation of arterial blood pressure and volume and in the local counter-regulation of cardiac hype...
متن کاملSubcellular trafficking of guanylyl cyclase/natriuretic peptide receptor-A with concurrent generation of intracellular cGMP
Atrial natriuretic peptide (ANP) activates guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), which lowers blood pressure and blood volume. The objective of the present study was to visualize internalization and trafficking of enhanced GFP (eGFP)-tagged NPRA (eGFP-NPRA) in human embryonic kidney-293 (HEK-293) cells, using immunofluorescence (IF) and co-immunoprecipitation (co-IP) of e...
متن کاملFunctional silencing of guanylyl cyclase/natriuretic peptide receptor-A by microRNA interference: analysis of receptor endocytosis.
Guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) is the principal receptor for the regulatory action of atrial and brain natriuretic peptides (ANP and BNP) and an important effector molecule in controlling of extracellular fluid volume and blood pressure homeostasis. We have utilized RNA interference to silence the expression of GC-A/NPRA gene (Npr1), providing a novel system to stud...
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ژورنال
عنوان ژورنال: JACC: Heart Failure
سال: 2015
ISSN: 2213-1779
DOI: 10.1016/j.jchf.2015.04.013